Lancet Diabetes The PIONEER-AF-PCI trial is the largest RCT n=2124 to date comparing triple therapy with warfarin vs a DOAC (i.e.

While noninferior to placebo for the primary MACE endpoint, the GLP-1 agonist was linked with a mortality benefit in patients with type 2 diabetes. Anticoagulation plus either one or two antiplatelet agents may be associated with better safety outcomes in patients with non-valvular atrial fibrillation (AFib), according to the results of the PIONEER AF-PCI Trial presented Nov. 14 during AHA 2016 and simultaneously published in the New England Journal of Medicine. Mosenzon O, Blicher TM, Rosenlund S, et al.
Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre, open-label, randomised, phase 3a trial Previous Article Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial Oral Semaglutide and Cardiovascular Outcomes in Diabetes Safety data exist for subcutaneous semaglutide, a glucagon-like peptide-1 receptor agonist, but not for the oral form.

The PIONEER 5 study was a multicenter, double-blind, randomized, placebo-controlled, phase 3a trial where 324 participants, age ≥ 18yrs, with type 2 diabetes, HbA1C 7.0-9.0% and moderate renal impairment (eGFR 30-59 mL 2 It was a randomised, double-blinded, placebo-controlled trial
Headline results from the PIONEER 6 trial of oral semaglutide demonstrate that the investigational GLP-1 receptor agonist is non-inferior to placebo with regard to major adverse cardiovascular events (MACE). ... (UPDATED) An oral version of semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist currently available as a once-weekly injection, successfully cleared a cardiovascular safety hurdle in the PIONEER … About PIONEER 6 and the PIONEER clinical trial programme PIONEER 6 was an event-driven, pre-approval cardiovascular outcomes trial for oral semaglutide.

rivaroxaban). It also compared dual therapy with rivaroxaban to triple therapy with warfarin.

Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial.

1,2,3,4 DESIGN

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