They are different from anti-bacterial drugs or antibodies. Antiviral drug, any agent used in the treatment of an infectious disease caused by a virus. Mutations in the TK gene may lead to an ablation of this enzyme, thus conferring cross-resistance between ACV, PCV, and other compounds that require this phosphorylation step. An antiviral drug will try to inhibit the virus at various stages of the life cycle of the infection of virus. Nonselective antiviral drugs: Ribavirin, Lamivudine, Interferon alpha. It may shorten the time it takes to recover from the infection. Antiviral drugs are those medications available or developed to either cure or control viral infections. For these reasons, particularly compared with antibacterial drugs, antiviral drugs are characterized by a narrow therapeutic margin. Antiviral drugs can be divided into three classes depending upon their mechanisms of action. Reverse transcriptase c. RNA polymerase 4. Examples of antiviral drugs include agents to combat herpes viruses, influenza viruses, and HIV. School of Molecular and Biomedical Science, The University of Adelaide and the Center for Cancer Biology, SA Pathology, Adelaide, SA, Australia . Taken up by cells 2. Mode Of Action Of Antiviral Drugs. Antiviral drugs are a class of medication used for treating viral infections. They act in different ways depending on the type of infection or virus.
The first class is of the substances that selectively inhibit viral functions without any significant influence on the metabolism of uninfected cells. 4. Mechanisms of Action of Antiviral Drugs: The Interferons. Converted by viral and cellualr enzymes to the triphosphate form 3. As of 2020, remdesivir is being tested as a specific treatment for COVID-19, and has been authorized for emergency use in the U.S. and approved for use in Japan for people with severe symptoms. Antiviral agents generally are designed to block viral replication or disable viral proteins. Search for more papers by this author. Remdesivir is a broad-spectrum antiviral medication developed by the biopharmaceutical company Gilead Sciences. General Mechanism of Action of Nucleoside Analogues: 1. Nephrotoxicity is emerging as an adverse reaction to antiviral drugs in human medicine. Edmund Tse MBBS, FRACP.
The second class is of the substances that in the infected cells are converted by a viral enzyme to compounds which inhibit virus replication. Resistance-conferring mutations can be detected in the target proteins involved in the mechanism of action of each of the drugs. Michael R. Beard PhD.
The triphosphate form inhibits: a. DNA polymerase b.